CFTR and Rare hereditary thrombophilia: The results of the first level diagnostic investigations (pelvic ultrasound for the woman and spermiogram for the man) constitute a decision-making step for the specialist and start the second level of investigations (for male pelvic ultrasound, karyotype, analysis of Y microdeletions and CFTR gene analysis; for female, evaluation of the hormonal profile, genetic tests for thrombophilia and recurrent pregnancy loss).