Making use of gene co-expression analysis in human brain samples and Drosophila PD models, Sun et al. demonstrated that SMARCA4 was upregulated with aging and a down-regulation of SMARCA4 via siRNAs (drosophila: Brm) in dopaminergic neurons restored life span, indicating possible future diagnostic and therapeutic approaches based on SMRCA4 [198]. The gene discussed is SMARCA4; the disease is Parkinson disease.