Alcohol intake of more than 30 g per day in men or 20 g per day in women was also associated with higher risk of SAMS [43]; in this case, the increase in reactive oxygen species generation by chronic alcohol consumption was associated with a decrease in ATP synthase and NADH-dehydrogenase enzymatic levels [44]. The gene discussed is ENSG00000254051; the disease is short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome.