Again, the impact that Lf has on iron metabolism may be related to its anti-cancer mechanism, as previous studies showed that Apo-Lf, but not Holo-Lf, induced apoptosis in HeLa cells and modified the expression of proapoptotic proteins such as BAX, which was increased in the presence of Lf, unlike Bcl-2 and Mcl-2, which decreased its expression [94]. This evidence concerns the gene LTF and cancer.