Furthermore, Tao et al. demonstrated that the synthetic flavonoid Gen-27 inhibited glycolysis and induced apoptosis of breast cancer (1H-I, MDA-MB-231, MCF-7, and MDA-MB-468) cells by suppressing HKII and consequently weakening interactions between HKII and voltage-dependent anion channels (VDAC) [169]. Here, HK2 is linked to breast cancer.