Similarly, quercetin inhibited HIF-1α accumulation, as well as HIF-1α protein synthesis under hypoxic conditions in several cancer cell lines, including LNCaP prostate cancer cells, SkBr3 breast cancer cells, and CX-1 colon cancer cells, and suppressed HIF-1α protein synthesis in a concentration-dependent manner[120]. This evidence concerns the gene HIF1A and malignant colon neoplasm.