To further explore the relationship between ACE2 and the IFN-I response, we examined the ability of IFNβ to promote ex vivo the expression of ACE2 (all isoforms) and ISG15 in cells from oropharyngeal swabs of six CF subjects (median age: 33 years; 2 males) and six matched healthy controls (median age: 31.5 years; 3 males). Here, ISG15 is linked to cystic fibrosis.