In fact, reduced levels of Grp94, as it occurs early in unloading-induced atrophy, jeopardize the targeting of newly synthesized nNOS molecules at sarcolemma and result in increased enzyme concentration in the sarcoplasm [28,29,30], where nNOS fosters both oxidative and nitrosative stresses and FoxO3 activation, as discussed at point 2.2.2 (Figure 1 and Figure 3). This evidence concerns the gene NOS1 and Atrophy.