These cytokines, either released at distant sites, in the case of tumor-induced cachexia [50], or locally, from skeletal muscle and neighboring tissues, in denervation- and disuse-induced atrophy [51,52], activate the NF-κB pathway, fostering NF-κB activity and cytokine production and generating a vicious circle. This evidence concerns the gene NFKB1 and Cachexia.