Within the TME, the protein complex S100A8/S100A9 is expressed and released by cells of granulocytic and monocytic origin, such as tumor-associated macrophages (TAM) supporting vascular invasion and neoangiogenesis by degrading the extracellular matrix and by inducing myeloid-derived suppressor cells (MDSC) [2,3]. The gene discussed is S100A8; the disease is neoplasm.