These activated by eotaxin-1 specific eosinophils are mainly implicated in allergic diseases (such as atopic dermatitis, allergic rhinitis, and asthma), parasitic infections, and inflammatory diseases characterized by eosinophil accumulation in tissues (eosinophilic esophagitis, gastroenteritis, and pneumonia). This evidence concerns the gene CCL11 and eosinophilic esophagitis.