CNR1 and Ehlers-Danlos syndrome: Following to that, a recent study reported that CB1R availability was inversely associated with BMI in homeostatic brain regions of HYP and brainstem both in ED patients and healthy controls, while in the mesolimbic reward system (amygdala, insula, midbrain, striatum, and orbitofrontal cortex), negative correlation was found only in EDs patients [133].