Defects in the endocannabinoid signaling, mediated primarily by CB1R, have been also implicated in development of binge eating disorder (BED), characterized by recurrent episodes of binge eating, with no compensatory behaviors to prevent weight gain, such as vomiting or laxative abuse [150]; therefore, obese individuals are the most commonly affected by BED [151]. Here, CNR1 is linked to X-linked cone dysfunction syndrome with myopia.