S100A8 and thrombocytosis disease: Characteristics of systemic inflammation are blood leukocytosis, neutrophilia, thrombocytosis, anemia, increased erythrocyte sedimentation rate (ESR), elevated CRP and SAA, and myeloid-related protein 8 and 14 (MRP8/MRP14, also known as S100A8/S100A9) [84,85,86].