NLRP3 and cryopyrin-associated periodic syndrome: Whereas Kuemmerle-Deschner et al. stated that patients with frequent VUS in the NLRP3 gene were at lower risk for eye disease, hearing loss, and renal involvement [23], Theodoropoulou et al. concluded that patients with clinical CAPS phenotype and Q703K variants had a comparable complication risk to patients with pathogenic NLRP3 gene variants [24].