Additionally, ILC2 numbers have been shown to correlate with infiltrating MDSCs in recurrent bladder cancer, where ILC2-derived IL-13 upregulated the expression of T cell-suppressing genes including ARG1 (encoding arginase-I; ARG1) and NOS2 (encoding inducible nitric oxide synthase; iNOS) [63]. This evidence concerns the gene NOS2 and urinary bladder cancer.