Knockdown of hypoxia-induced triggering receptors expressed on myeloid cells (TREM)+PD-L1+ TAMs in advanced hepatocellular carcinoma (HCC) could successfully rescue CTLs from an exhaustive state and restore their cytolytic activity, which was largely attributed to a reduced recruitment of Tregs to the TME [186]. The gene discussed is CD274; the disease is hepatocellular carcinoma.