In our present analyses, we evaluated the efficacy of evogliptin in suppressing the in vitro osteogenesis of VICs, inflammatory cytokine expression, and the formation of calcific lesions in CAVD animal models to elucidate the mechanism by which DPP-4 inhibitor attenuates CAVD. The gene discussed is DPP4; the disease is congenital bilateral aplasia of vas deferens from CFTR mutation.