Compound PI-103 (Figure 3) was tested on a panel of T-ALL cell lines and primary patients’ cells with constitutive activation of PI3K/Akt/mTOR pathway, showing potent cytotoxicity accompanied by complete inactivation of AKT, p70S6K, ribosomal S6 protein, and 4E-BP1 [87]. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.