Its analog, AZD2014 (vistusertib), had superior pharmacokinetics [36] and a good tolerability profile [37]; on AML cells, it showed synergistic effects with the antibody-drug conjugate gemtuzumab ozogamicin by activation of lysosomal function [38] and with the pan-PIM inhibitor AZD1208 [39]. The gene discussed is PIM1; the disease is acute myeloid leukemia.