Gilteritinib (ASP2215; Figure 5) is a type I kinase inhibitor based on a pyrazine-carboxamide scaffold showing sub-nanomolar potency against FLT3 and AXL, activity against resistance-conferring mutations of FLT3 in cells, and a favorable pharmacokinetic profile granting activity on AML xenograft models [84]. Here, FLT3 is linked to acute myeloid leukemia.