NVP-BAG956, acting at two levels along the PI3K/mTOR pathway, showed potent cytotoxic effects against T-ALL cell lines and primary patients’ samples, outperforming drugs hitting a single target, such as PI3K, mTOR, or AKT inhibitors, which achieved comparable effects when combined, however [164]. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.