MTOR and acute myeloid leukemia: PIM signaling has a role in defining cell fate, including senescence, cell cycle regulation, apoptosis, metabolism, invasion, and metastasis; PIM1 mRNA levels are increased in acute myeloid leukemia (AML); thus, the combination of a PIM kinase inhibitor with an mTOR inhibitor is expected to offer greater antitumor effects in AML than either inhibitor alone [53].