MSH2 and cancer: Besides BRCA1/2, a significant proportion of CNVs was identified in non-BRCA1/2 genes, affecting 33 of the 4208 patients (0.76%), mostly in the ATM, CHEK2, and RAD51C cancer predisposition genes and less frequently in BARD1, MLH1, MSH2, PALB2, PMS2, RAD51D, and TP53.