Accordingly, as part of tumor microenvironment, TILs are able to release VEGF-A and inflammatory cytokines, showing immunosuppressive effects [41], including the formation of new blood vessels by acting on endothelial cells [42] and enhancing the inflammatory processes by increasing hypoxia inducible factor 1-alpha (HIF-1α) and VEGF-A synthesis [13]. The gene discussed is HIF1A; the disease is neoplasm.