In an acidic tumor microenvironment, fructose-bisphosphate aldolase A (ALDOA), pyruvate kinase muscle isozyme M2 (PKM2,) and lactate dehydrogenase A (LDHA) are overexpressed in colon cancer, resulting in high acidity of the intracellular environment. This evidence concerns the gene LDHA and malignant colon neoplasm.