FASLG and Familial prostate cancer: ISL can induce prostate cancer cell apoptosis via increasing Fas ligand (FasL), Fas, cleaved casapse-8, tBid, cytochrome c, and Smac/Diablo (ISL shows an estimated IC50 of 13.74, 5.67, and 5.01 μM in the MAT-LyLu cell line treated for 24, 48, and 72 h, respectively; in contrast, it shows an estimated IC50 of 56.87, 31.49, and 17.60 μM in the MAT-LyLu cell line treated for 24, 48, 72 h, respectively) [118].