Finally, in some cancer cells in which PDHα protein level and PDC activity are increased (Chen et al., 2018; Dolezal et al., 2017; Marin‐Valencia et al., 2012) the supply of mitochondrial acetyl‐CoA for increased de novo biosynthesis of lipids as well as protein acetylation in the cytoplasmic/nuclear compartment is supported for rapid growth (Dolezal et al., 2017; Marin‐Valencia et al., 2012). This evidence concerns the gene PDHA1 and cancer.