Since the PDK/PDH axis is modified via increased expression of HIF‐1α in several tissue‐specific cancers, we quantified gene expression of three PDKs, and observed that the mRNA levels of HIF‐1a and PDK1 were significantly decreased whereas that of PDK2 and PDK4 remained unaltered in L‐PDCKO livers compared with L‐PDCCT livers (Figure 4). This evidence concerns the gene PDK4 and cancer.