HIF1A and hepatocellular carcinoma: As expected, DEN-induced HCC resulted in a marked increase of CD11b+Ly6C+Ly6G- monocytes and CD11b+Ly6C-F4/80+Tim4- monocyte-derived macrophages (MoMfs) in the liver, which was most pronounced in mice treated with HIF-1α ASO (Figure 5).