These genetic targets comprise multiple cancer hallmark-implicated genes, including genes involved in 1) angiogenesis, such as vascular endothelial growth factor (VEGF), erythropoietin (EPO) and platelet-derived growth factor (PDGF); 2) metabolism, such as glucose transporter 1 (GLUT1), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and phosphoglycerate kinase 1 (PGK1); 3) proliferation, such as insulin-like growth factor 2 (IGF-2) and transforming growth factor (TGF)-α; and 4) invasion and metastasis, such as lysyl oxidase (LOX) and several matrix metalloproteinases (MMPs). The gene discussed is GAPDH; the disease is cancer.