NUS1 and hemangioma: Based on the intensive expression of NGBR in proliferating infantile hemangioma and NICH, but not in involuting hemangioma and RICH, our favorite hypothesis is that highly expressed NGBR promoted the growth of proliferating hemangioma via NGBR-mediated RAS recruitment and RAS-dependent RTK signaling pathways (Supplemental Figure 7).