In contrast to our observations of downregulation of MMPs, in animal models with induction of cardiac hypertrophy, MMPs are often found to be upregulated, i.e., under AngII infusion, induction of MMP-7 was shown [34]; under norepinephrine infusion [35] or pressure overload [8], MMP-2 was induced. This evidence concerns the gene AGT and cardiac hypertrophy.