In addition, as the ageing brain typically includes multiple pathologies which together can lower the threshold for one specific pathology to cause dementia (or other neurological impairment) [4, 12, 28], the neuropathological report should contain information on all observed pathologies, e.g., AD neuropathological change [19], TDP-43 pathology [16, 21], cerebrovascular pathology [24], and LP. This evidence concerns the gene TARDBP and Alzheimer disease.