As reported above, ICC-SM express T-type channels Cacna1h and Cacna1g. Therefore, the role of T-type Ca2+ channels in modulating Ca2+signaling in ICC-SM was evaluated with specific T-type channel antagonists, NNC 55–0396 (10 μM), TTA-A2 (10 μM) and Z-944 (1 μM). This evidence concerns the gene CACNA1H and intrahepatic cholangiocarcinoma.