Kit receptors and ANO1 channels are signatures of ICC throughout the GI tract and enrichment of Kit and Ano1 expression was observed in sorted ICC-SM compared to unsorted cells (Kit expression was 0.21 ± 0.014; Ano1 expression was 0.14 ± 0.02 relative to Gapdh). Here, GAPDH is linked to intrahepatic cholangiocarcinoma.