TNF and infection: This is in contrast to previous findings of interferon pathway dysregulation via STAT1/STAT2 nuclear translocation blocking by the p6 protein [47] Nevertheless, our transcriptomic analyses revealed an enhanced upregulation of 9 immune-related genes in the NF-kB pathway, including those coding for inflammatory cytokines such as chemokines, IL1A and TNFα, specifically induced by the infection of partial ORF6 deletions.