Additionally, three independent preprint studies based on full-genome loss of function CRISPR screens recently demonstrated that SARS-CoV-2 can hijack autophagy-related genes transmembrane protein 41B (TMEM41B) or 106B (TMEM106B) to promote viral infection and replication, while the intact autophagy pathway is not required [54–56]. The gene discussed is TMEM41B; the disease is viral infectious disease.