Interestingly, crest mutant mice often develop infertility (Aizawa et al. 2004) and a series of proteins interacting with CREST are found closely related to the differentiation and maturation of the spermatogenic epithelial cells (Gye et al. 2001; Don and Stelzer 2002; Boussouar et al. 2014; Carre et al. 2018). Here, SS18L1 is linked to Infertility.