Our results showed that high FTX expression was significantly associated with several clinicopathological characteristics, including lymph node metastasis in patients with CRC, GC, HCC, and RCC; distant metastasis in patients with CRC, GC, HCC, and OSC; bigger tumor size in patients with CRC, GC, HCC, RCC, and OSC; and later TNM/clinical stage in patients with CRC, GC, HCC, OSC, and glioma. The gene discussed is FTX; the disease is central nervous system cancer.