Importantly, human tissue distribution of ACE2 and TMPRSS2 mirrors organ system involvement in COVID-19 and includes the lungs6-11, vascular endothelium9-12, heart11,13,14, kidneys8,10,13, liver8,10, digestive tract8,10,11,15, nasal epithelium7,10,11 and central nervous system10,14. The gene discussed is ACE2; the disease is COVID-19.