SLC40A1 and Cognitive impairment: To determine the precise role of Fpn in brain iron metabolism and cognitive impairment, we generated conditional knockout mice of Fpn (Fpnfl/fl/NEXcre) by crossing the Fpnfl/fl mice with NEX-Cre mice, which expressed Cre recombinase in the excitatory neurons of the neocortex and hippocampus.