Emerging evidence has suggested that ferroptosis could be discovered in the neuronal cell death associated with various neurological diseases, such as hemorrhagic stroke, ischemic stroke, Parkinson’s disease and Huntington’s disease, accompanied by lipid peroxidation, mitochondrial dysfunction and reduction of glutathione peroxidase 4 (GPX4) [12–16]. This evidence concerns the gene GPX4 and Huntington disease.