A recent study demonstrated that the NGF is associated with genes involved in neuroendocrine differentiation from a gene expression profile of prostatic CXCR2+ neuroendocrine tumor cells, and it was also enriched in SCNC samples compared to CXCR2− luminal prostate cancer cells and primary adenocarcinoma cases58. The gene discussed is NGF; the disease is neuroendocrine neoplasm.