Remarkably, we found that for most cancer types patient tumours tend to have high mutation frequencies in genes involved in either the ERK1/2 pathway or the p38 and JNK pathways, but rarely in the genes involved in both the ERK1/2 pathway and p38 and/or JNK pathways (Fig. 2c and Supplementary Fig. 2b). This evidence concerns the gene MAPK8 and neoplasm.