These multicentre findings also confirm pilot data where a negative correlation between epithelial cell density and diffusivity was demonstrated in 15 lesions excised at IDS in participants with primary ovarian or peritoneal cancer,4 and in 24 participants with prostate cancer.20 In orthotopic preclinical models of solid ovarian tumours, the change in ADC following docetaxel also was shown to correlate negatively with Ki67, CA125 and Bcl-2, all of which predict residual tumour burden.21 Here, MKI67 is linked to neoplasm.