TBX1 and cancer: Identification of specific examples of molecular crosstalk between CAFs and TNBC cancer cells, such as these, presents opportunities for inhibition of the interactions and therefore chemo-sensitisation to improve TNBC outcomes.10 Our hypothesis was that CAFs directly modulate responses of TNBC cells to cytotoxic chemotherapy, and therefore that the differential responses of tumours may be driven in part by impact of variable CAF activity.