NLRP3 and Parkinson disease: When we considered NLRP3 as a binary variable, there was clearly a higher proportion of PD patients with detectable EV-borne NLRP3 [EVs: n = 31 (31% of PD)] compared with controls [EVs: n = 11 (18% of controls)] (P = 0.11), whereas the crude plasma NLRP3 levels did not differ by PD status (plasma: n = 17 (17% of PD) n = 8 (13% of controls) (P = 0.68).