A growing body of evidence linking the NLRP3 inflammasome with PD includes recent reports characterizing a Nlrp3 inflammasome response to fibrillar α-synuclein exposure26,27, ROS production28, and the occupational toxicant manganese29; three sterile, inflammatory triggers associated with the development and pathophysiology of PD30. Here, NLRP3 is linked to Parkinson disease.