In contrast, other genes frequently mutated in previous studies [22, 38, 45], such as HLA-B, NFE2L2, EP300, FBXW7, ARID1A, SHKBP1, ERBB3, and CASP8, were not confirmed in our study, probably because of the heterogeneity of tumor origins in previous studies. The gene discussed is EP300; the disease is neoplasm.