APP and Alzheimer disease: In this region, we identified 27 and 17 DEGs/gDTUs in the MSBB_TL and Mayo datasets, respectively, including some well-characterized AD risk genes, such as ADAM10 (ADAM metallopeptidase domain 10), BIN1, CLU (Clusterin), and TREM2 (triggering receptor expressed on myeloid cells 2), and the causal AD genes APP, PSEN1 and 2 (presenilin 1 and 2) (Fig. 8A, B).