Ischemia-induced heart failure is a consequence of impaired perfusion of the heart, and new blood vessel formation is a critical component of wound healing.15 We observed a significant reduction in the endothelial markers Pecam1 and Vegf1 in the infarcted Zeb2 cKO hearts when compared to Zeb2 fl/fl controls (Fig. 2k–l), which corresponded with an overall decrease in the percentage of PECAM1 positive vessels in the remote and border zone (Fig. 2m–p). Here, ZEB2 is linked to heart failure.