PECAM1 and heart failure: Ischemia-induced heart failure is a consequence of impaired perfusion of the heart, and new blood vessel formation is a critical component of wound healing.15 We observed a significant reduction in the endothelial markers Pecam1 and Vegf1 in the infarcted Zeb2 cKO hearts when compared to Zeb2 fl/fl controls (Fig. 2k–l), which corresponded with an overall decrease in the percentage of PECAM1 positive vessels in the remote and border zone (Fig. 2m–p).