Evaluation of MTBVAC- and TB peptide-pool-specific T-cell cytokine production revealed a predominantly Th1 response profile from poly- (IFN-γ+TNF-α+IL2+) and multi- (IFN-γ+TNF-α+) functional CD4 T cells, while only low levels of Th22, Th17 and cytokine-producing CD8 T-cell populations were detected. This evidence concerns the gene TNF and tuberculosis.