A single nucleotide variant in ITIH3 has been associated with heightened risk for myocardial infarctions, possibly due to its effect on increasing ITIH3 expression46, while platelet-derived growth factor (PDGF) signaling contributes to the development of various age-associated lung diseases, such as pulmonary arterial hypertension and fibrosis47,48. Here, ITIH3 is linked to pulmonary arterial hypertension.