In agreement with incomplete inhibition of pro-inflammatory signaling in response to low MOI Yersinia infection, infection of macrophages at 7.5 MOI induced IL-1β release that was dependent on TRIF, TNFR1, ZBP1, and RIPK1 kinase activity (Fig. 6e). The gene discussed is TICAM1; the disease is Yersinia infectious disease.