In further support of the importance of the TRIFosome in Yersinia infection, cleavage of CASP8 was inhibited nearly entirely in the absence of TRIF, and partially in the absence of ZBP1 and RIPK1 kinase activity in the context of high MOI Yersinia infection (Fig. 6d). Here, CASP8 is linked to Yersinia infectious disease.