Since disruption of this ZNF143-CTCF regulatory axis results in a severe anemia phenotype in both embryos and adults, in the agreement of ubiquitous expression and high homology of both ZNF143 and CTCF among mammals, the regulation of CTCF-bound loops controlled by ZNF143 might contribute to multiple physiologic and disease processes. Here, ZNF143 is linked to anemia.