After analyzing and filtering, we found three dHMN patients from family 1, 2, and 3 carrying the known homozygous c.757delG (p.Ala253GlnfsTer27) variant in SORD. Furthermore, two novel variants were detected in the proband (dHMN) of family 4, including a missense variant c.404 A > G (p.His135Arg) and a splicing variant c.908 + 1 G > C. Here, SORD is linked to distal hereditary motor neuropathy.