WNK2 and cardiomyopathy: Furthermore, KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis indicated that pathways involved in cardiomyopathies, regulation of actin cytoskeleton, cardiac muscle contraction and adhesion, mitogen-activated protein kinase signaling, Rap1 signaling, and adrenergic signaling were the most significantly altered biological pathways (Fig. 4C).