USP47 overexpression in YB-1 and/or Polβ depletion cells cannot abrogate γH2AX expression, indicating that YB-1 contributes more to USP47-mediated DNA damage repair than Polβ in CML cells (Supplementary Fig. 6f). Here, POLB is linked to chronic myelogenous leukemia, BCR-ABL1 positive.