To establish how T-cell specific loss of RORα affected autoimmune disease development, we immunized Rorafl/fl and Rorafl/fl × CD4 Cre mice with MOG35–55 peptide/complete freund’s adjuvant (CFA) plus pertussis toxin to induce experimental autoimmune encephalomyelitis (EAE), a commonly used TH17-dependent mouse model of chronic-progressive MS24,25. The gene discussed is CD4; the disease is experimental autoimmune encephalomyelitis.