In contrast, expression of the sIL11RA in hepatocytes of KOs, which would theoretically activate trans-signaling as IL11 levels are already elevated, had no effect despite very high IL11RA levels (Fig. 6b; Supplementary Fig. 10b, 11b and c) and mice remained protected from NASH (Fig. 6c–j; Supplementary Fig. 10c, 10d, 11d–k). This evidence concerns the gene IL11 and metabolic dysfunction-associated steatohepatitis.