Restoration of IL11 cis-signaling in KO mice using mbIl11ra1 recapitulated hepatic steatosis and inflammation that was evident from gross morphology to molecular patterns of gene expression and signaling (Fig. 6c–h, j and k; Supplementary Fig. 10c, 11d–h, 11j, 11l). The gene discussed is IL11; the disease is fatty liver disease.