To further study the inhibitory function of VE-822 on tumor growth, we bore xenograft tumors in nude mice with a HeLa monoclonal cell line with inducible CA (TETON-PLK4 cell line, the percentage of CA was from 11% up to ~80% after doxycycline treatment)2,43,44, or MDA-MB-231 cells (with high-frequency of CA). The gene discussed is PLK4; the disease is neoplasm.