The γ-tubulin staining of tumor sections identified that the KIFC1-S26D xenograft tumors showed a significant increase in the frequency of centrosome clustering coupled with a marked decrease of the frequency of multipolar mitosis, and etoposide treatment specifically increased centrosome clustering in the KIFC1-WT but not the KIFC1-S26A/D xenograft tumors (Fig. 6f). Here, KIFC1 is linked to neoplasm.