LAMP3 encodes the lysosomal-associated membrane protein 3, which plays a role in the unfolded protein response that contributes to protein degradation and cell survival during proteasomal dysfunction.30 Furthermore, LAMP3 knockdown impairs the ability of the cells to complete the autophagic process, and high LAMP3 expression is associated with increased basal autophagy levels.31 Numerous PD-related genes have been implicated in the autophagy-lysosomal pathway,32 and genes associated with iRBD such as GBA,33TMEM175,34 and SNCA14 are involved in this pathway. This evidence concerns the gene GBA1 and Parkinson disease.