RUNX1 and acute myeloid leukemia: Recurrent translocations include t(8; 21), t(3; 21), and t(12; 21), which result in the fusion of part of the RUNX1 protein to all or part of another protein—ETO, EVI1, and ETV6 in the examples given—and are found in AML, chronic myelogenous leukaemia, and acute lymphoblastic leukaemia (Miyoshi et al, 1993; Mitani et al, 1994; Golub et al, 1995; Romana et al, 1995).