According to a study of adjuvant-induced arthritis in rats’ synovium, inhibition PPAR-γ expression by T0070907 or PPAR-γ siRNA could significantly promote the proliferation of fibroblast-like synoviocytes and expressions of c-Myc, Cyclin D1, MMP-1, and MMP-9, except for TIPM-1 [31, 36]. Here, MMP1 is linked to arthritic joint disease.